Potential Effect of Fibroblast Growth Factor (FGF2) Versus Epidermal Growth Factor (EGF) on Healing of Induced Oral Ulcer in Albino Rats (A Histological and Immunohistochemical Study)

Document Type : Original Article

Authors

1 Demonstrator of Oral and Dental Biology, Faculty of Dental Medicine Girls branch, Al- Azhar University.

2 Professor and Head of Oral and Dental Biology Department, the Former Dean of Faculty of Dental Medicine Girls branch, Al- Azhar University.

3 Assistant Professor of Oral and Dental Biology, Faculty of Dental Medicine Girls branch, Al- Azhar University.

Abstract

Aim: The aim of the present study was to evaluate the effect of human recombinant Fibroblast growth factor (FGF2) and Epidermal growth factor (EGF) on healing of mechanical
induced buccal mucosal ulcers in albino rats. Materials and Methods seventy five adult male albino rats (weight 200-250gm) each were used in the study. Rats were divided into 4 groups (group1, group2, group 3 &group 4) : G2 negative control, G3 received FGF, G4 received EGF, then each group was divided into 4 subgroups according
to the date of scarification at 1,4, 7, 10 days postoperatively ulcers were induced by punch biopsy apparatus (5 mm diameter). Growth factor (FGF or EGF) was applied by using microliter syringe, the specimens were processed for histological and immunohistochemical
analysis. Results: EGF and FGF promoted proliferation of fibroblast, EGF promoted proliferation of keratinocyte. Conclusion: Both growth factors accelerate
wound healing compared with control group. rh FGF restores collagen production, while rh EGF can induce rapid wound healing by accelerating the proliferation of new epithelial cells.

Keywords

Al-Azhar Dental Journal for Girls
Volume 5, Issue 1
January 2018
Pages 23-27

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