Role of Stem Cells in Transport Distraction Osteogenesis for Reconstruction of Mandibular Defects after Segmental Mandibulectomy

Document Type : Case Studies


1 MSc student, Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.

2 Professor of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.

3 Professor and Head of Oral and Maxillofacial Surgery Department, Deraya University, Menya, Egypt.

4 Consultant and Head of Maxillofacial Surgery department, Nasr City for Health Insurance Hospital, Cairo, Egypt.


Purpose: to restore the continuity and functions of the mandible after segmental mandibulectomy for mandibular defect reconstruction by using a technique of transport distraction osteogenesis with stem cells injection. Subjects and methods: Clinical study was conducted on eight patients suffering from mandibular deficiency after tumor resection. All steps of manufacturing of the transport distractor, tumor resection and segmental mandibulectomy of transport disc were guided by Stereolithographic (STL) model. Stem cells sample was prepared to be injected along the soft callus at the end of the activation period. Patients were followed up postoperative clinically every week and radiographically by Panoramic x-ray and computed tomography (CT) at immediate postoperatively, then by panoramic x-ray monthly along the periods of distraction and finally by multi slice CT at the end of the consolidation to evaluate the time consuming for treatment. Results: seven cases out of eight cases recorded excellent distraction regenerate and excellent soft tissue coverage and one case out of these eight cases in the control group failed at the first week of activation. Multi slice CT showed a significantly higher value in the mean of the regenerated bone density at the end of the consolidation (1163.76±111.38) in the study group than the control group (747.67±268.6). Conclusion: From our study, stem cells injection in the distraction regenerate for reconstruction of mandibular defect cases achieved short consolidation period and high regenerated bone density.


Main Subjects

Volume 10, Issue 2
Issue2 April- Oral Medicine & Surgical Sciences issue (Oral Medicine, Oral & Maxillofacial Surgery, Oral Pathology, Oral Biology)
April 2023
Pages 441-449