Evaluation of Controlled Release Simvastatin around Dental Implant in Controlled Type II Diabetic Patient

Document Type : Original Article

Authors

1 Dentist at Medical Administration Center, Al-Azhar University, Cairo, Egypt

2 Professor of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dental Medicine for Girls Al-Azhar University & Faculty of Oral and Dental Medicine, Misr International University, Cairo, Egypt

3 Associate Professor of Pharmaceutics, Faculty of Pharmacy Al-Azhar University, Cairo, Egypt

Abstract

Purpose: The goal of this study was to evaluate the clinical effect of topically controlled release simvastatin with dental implant in type II diabetic patients. Materials and Methods: Sixteen diabetic type II patients with missing teeth were selected according to inclusion and exclusion criteria. Patients were divided randomly into two groups using flip coin method. Group I (test group): 8 patients underwent implant placement for missed tooth with controlled released simvastatin around the implant. Group II (control Group): 8 patients underwent implant placement for missed tooth without controlled released simvastatin around the implant. All patients were followed up clinically and radio-graphically for 6 months postoperatively after implant placement. Results: The use of Simvastatin controlled release gel with delayed dental implants decrease postoperative pain and swelling Conclusion: This research showed that the drug delivery system of controlled release simvastatin improve the repair and healing of bone and soft tissue around dental implant in diabetic type II patients

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Al-Azhar Dental Journal for Girls
Volume 10, Issue 1
Issue1 January- Oral Medicine & Surgical Sciences issue (Oral Medicine, Oral & Maxillofacial Surgery, Oral Pathology, Oral Biology)
January 2023
Pages 401-411

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