Evaluation of the Effect of Hyaluronic Acid Gel Loaded with Simvastatin on the Osseointegration and Stability of the Dental Implants

Document Type : Original Article

Authors

1 Oral and Maxillofacial Resident at Al-ahrar Teaching Hospital, Zagazig , Egypt

2 Professor of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt and Faculty of Dentistry, Deraya University, Minya, Egypt

3 Lecture of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egyp

Abstract

Purpose: The purpose of this study was to assess the clinical and radiographic outcomes of mandibular posterior edentulous area rehabilitation by fixed implantsupported prosthesis with or without use of Hyaluronic Acid Gel loaded with Simvastatin. Subjects and methods: Twelve implants were inserted in mandibular posterior edentulous region that required rehabilitation with fixed implant-supported prosthesis were included in this study. The patients were divided into 2 groups: Group A; the edentulous sites were treated by 6 implants which were inserted with the application of Hyaluronic acid (HA) gel loaded with Simvastatin (SMV) in the drilling site. Group B; Six dental implants were placed in edentulous sites without the use of HA gel containing SMV. The clinical follow-up was done at three and six months, whereas the radiographic follow-up was done at three and twelve months. Treatment changes were evaluated for each group and a comparison was done between the 2 groups. Data were analyzed to assess difference and association of qualitative variable by Chi square test (X2 ), paired by sign test and Differences between quantitative independent groups by paired t test. Results: Radiographically; at 3 and 12 months, there was a statistically significant difference in bone density between two groups. While, there was no statistically significant difference in implant stability between two groups immediately and after 3months.Conclusion: Application of HA gel loaded with SMV around dental implant improves the implant stability and bone density around the implant which enhances the osseointegration of implant.

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Al-Azhar Dental Journal for Girls
Volume 10, Issue 1
Issue1 January- Oral Medicine & Surgical Sciences issue (Oral Medicine, Oral & Maxillofacial Surgery, Oral Pathology, Oral Biology)
January 2023
Pages 393-400

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