Molecular Assessment of Kallikrein 3 in Ameloblastoma and Odontogenic Keratocyst

Document Type : Original Article

Authors

1 Oral pathology, faculty of dentistry, Ahram candian university, 6th of October city, Egypt

2 Lecturer of medical biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.

3 Associate Professor of Oral and Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.

4 Professor of Oral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University, Cairo, Egypt

5 Professor and Head of Oral and Dental pathology Department Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo Egypt

Abstract

Purpose: The current research was conducted to assess KLK3 at molecular and protein level in AB and OKC to shed more light on its role on biologic behaviour of these lesions. Material and methods: 30 paraffin embedded blocks of AB, OKC and Dentigerous Cyst (DC) as a control were included. Immunohistochemical staining technique with KLK3 antibody was applied to all the tissue blocks and RT-PCR KLK3 gene were done for all specimens. Results: The mean area percent of KLK3 expression was significantly greater in AB and OKC compared with DC. According to the current study, presence of significant difference between AB and OKC in relation to control indicates that KLK3 antibody is related the aggressive biologic behaviour of AB and OKC. Conclusion: Increased expression of KLK3 protein and gene expression in AB and OKC suggests that KLK3 may have a role in the intrinsic and limitless growth potential of these lesions.

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Al-Azhar Dental Journal for Girls
Volume 10, Issue 1
Issue1 January- Oral Medicine & Surgical Sciences issue (Oral Medicine, Oral & Maxillofacial Surgery, Oral Pathology, Oral Biology)
January 2023
Pages 113-121

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