Evaluation of Glutathione Levels in Gingival Cervical Fluid in Periodontitis from Stage 1 – Stage 4 among Type 2 Diabetic Patients

Document Type : Original Article

Authors

1 Dentist at General Authority for Health Insurance B.D.S (2013) MUST University, Egypt.

2 Professor of Oral Medicine, Periodontology, Oral Diagnosis and Radiology Faculty of Dental Medicine for Girls, Al-Azhar University, Faculty of Oral and Dental Medicine – Misr International University, Cairo, Egypt

3 Lecturer of Oral Medicine , Periodontology, Oral Diagnosis and Radiology Faculty of Dental Medicine for Girls –Al-Azhar University, Cairo, Egypt

Abstract

Purpose: This study aimed to evaluate if glutathione could be used as a diagnostic biomarker in diabetic patients with stage 1, stage 2, stage 3, and stage 4 periodontitis who were receiving non-surgical periodontal therapy. Material and methods: Twentyeight participants were included, who were separated into four groups, each with seven members. Seven diabetic patients with stage 1 periodontitis were assigned to Group 1, seven diabetic patients with stage 2 periodontitis were assigned to Group 2, and seven diabetic patients with stage 3 periodontitis were assigned to Group 3 and Seven diabetic patients with stage 4 periodontitis were assigned to Group 4. Gingival crevicular fluid (GCF) samples were taken from every individual at baseline (before non-surgical periodontal therapy) and one month after non-surgical periodontal therapy was completed. Results: Glutathione levels in the four groups dramatically improved after non-surgical therapy. Conclusion: Glutathione levels should be considered important indicator for prognosis of the periodontal treatment in patients with periodontal disease.

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Al-Azhar Dental Journal for Girls
Volume 10, Issue 1
Issue1 January- Oral Medicine & Surgical Sciences issue (Oral Medicine, Oral & Maxillofacial Surgery, Oral Pathology, Oral Biology)
January 2023
Pages 159-164

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