Evaluation of the Antibacterial Effect of Grape Seed Extract on Streptococcus Mutans in Children

Document Type : Original Article


1 Dentist at Al-Azhar Medical Administration Girls Branch, Cairo, Egypt.

2 Assistant Professor, Head of Pedodontics and Oral Health Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.

3 Lecturer of Pedodontics and Oral Health, Faculty of Dental Medicine for girls Al-Azhar University, Cairo, Egypt.


Purpose: To evaluate the effect of grape seed extract on streptococcus mutans in children Materials and methods: Forty children were selected for this study with ages ranged from (7-12). The participants were divided into two equal classes at random; A& B (n= 20). Participants were asked to rinse with 15 ml of either grape seed extract or 0.125% CHX mouthwashes (in group A & B respectively) twice daily (after breakfast and dinner) for 60 seconds and not to rinse with water thereafter. Saliva samples were collected at 0 (baseline) (S1), after 2 days (S2) and after a week (S3). All collected saliva samples were submitted to a microbiology laboratory for total bacterial counting at the three intervals for the two groups, the data were then collected, tabulated, and statistically analyzed Results: The comparison between grape seed extract and CHX group showed that there was no statistically significant difference in the mean CFU between the two groups at different time intervals.(P-value=0.708,0.202,0.056) Conclusion: Grape seed extract mouthwash is considered a successful antimicrobial agent compared to a potent antiseptic as chlorhexidine when used in children.


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